Human immunodeficiency virus infection

Human immunodeficiency virus infection (HIV) is serious heath challenge to many nations of the world (Richter et al., 2004). It affects the innate and the acquired immune systems through different mechanisms which include impaired function of macrophages, which serve as the bridge between the innate and acquired responses by presenting antigen to CD41 T lymphocytes. HIV infection decreases immune function thereby reducing capacity to deal with subsequent pathogen exposure which will allow opportunistic infection to thrive . It is managed with highly active antiretroviral therapy (HAART). HAART is a combined preparation containing two to three classes of antiretroviral drugs. It used has decreased mortality and morbidity rate associated with HIV (Palella et al., 1998). However, the use of HAART could be associated with lots of toxicities. TELE is used as a HAART in HIV management (Montessori et al., 2004). Available reports showed it is efficacious however; there is paucity of information concerning its safety especially in black population. Therefore, this study examines the safety of TELE in HIV patients of African descent.
The liver is the primary organ for the detoxification and biotransformation of most antiretroviral drugs which may predispose it to damage (Sulkowski, 2004; Hazin et al., 2009). Biochemical markers which include alanine aminotransferase (ALT), alkaline phosphatase (ALP), and aspartate aminotransferase (AST), lactate dehydrogenase (LDH) and gamma glutamyl transferase are experimentally and clinically used to assess the detrimental effects of xenobiotic on the liver (Liss et al., 1985). The present study, observed normal levels of the above biochemical markers in HIV patients treated with TELE