Human and animals are absolutely depending on forests to survive. Forest plays significant roles namely provide vital oxygen that used by human and animal to breathe. Also, many people rely on forests for their livelihood. However, instead of our dependence, we still have less comprehensive about the crucial point of forest for our live (WWF, 2017). Nowadays, Amazon rainforest as the biggest rainforest in the world was reported would reach its point of no return. In other words, it might lose its ability to maintain its functions which also impact on the survival of human and animals (Science Advances, 2018). Amazon rainforest located in South America. It is the vast rainforest in the world for, it is spanning across eight countries such as Brazil, Peru, Colombia, Bolivia, Venezuela, Suriname, Ecuador, Guyana, and French Guiana, according to WWF, 2018 and Butler, 2017). Nevertheless, the biggest rainforest is now in a critical situation because of deforestation. Bradford (2018) define that “deforestation is the permanent destruction of forests in order to make the land available for other uses”. Deforestation occurs in many ways and therefore it has caused negative impacts on the environment, animals and plants, and the survival of the inhabitants of Amazonia. This essay will discuss some causes and effects of deforestation that occur in the Amazon rainforest.