Background Virological failure and immunological responses in HIV-infected adolescents on ART are globally the burdens in their Reproductive Health

Background Virological failure and immunological responses in HIV-infected adolescents on ART are globally the burdens in their Reproductive Health. In low and middle income countries, 2.2 million among infected people are the adolescents and their viral load monitoring for those on ART, accessibility in low-income countries remains limited. They attain virologic suppression which is shorter time to viral rebound and less experience long-term immunologic recovery despite initial CD4 T-cell counts. The objective is to investigate the virological and immunological responses to ART therapy and their relation to clinical outcomes among HIV-infected adolescents from 2017 to 2018. Problem statement The factors of adherence are the stigma, experienced and inadvertent disclosure of HIV status loaded adolescents from ART. Poor intellectual ability has 2.9 likely impairs adolescents adaptation in integrating ART taking into an already challenging daily life comparing to higher intellectual abilities. The Viral load monitoring for those on ART, accessibility in Rwanda countries remains limited. With the extension of ART program and coverage, monitoring of adolescents aged 10 to 19 poses a great challenge in the Health reproductive health in Rwanda. Specific objectives (1) Analyze the prevalence of virological and immunological among HIV infected adolescents (2) Explore the factors associated with the virological and immunological failure among HIV-infected adolescents (3) Examine the association of virologic and immunologic response with the clinical outcomes. Research questions (1) What is the prevalence of the virological and immunological outcomes in HIV infected adolescents (2) What are the factors associated with VL and immunological failure (3) Which is association between virologic and immunologic responses with the clinical outcomes Methods The study is retrospective cohort and cross-sectional studies of 300 participants are followed-up from 2016 to 2018. STATA will be used to analyze. Nachega JB, Hislop M, Nguyen H et al. (2009). Antiretroviral Therapy Adherence, Virologic and Immunologic Outcomes in Adolescents Compared With Adults in Southern Africa. Journal of acquired immune deficiency syndromes. 51(1)65-71. Xu L, Munir K, Kanabkaew C Le Coeur S. (2017). Factors influencing antiretroviral treatment suboptimal adherence among perinatally HIVinfected adolescents in Thailand. PLoSONE 12(2)e0172392.doi10.1371/journal.pone.0172392. PAGE MERGEFORMAT 1 Page Y, dXiJ(x(I_TS1EZBmU/xYy5g/GMGeD3Vqq8K)fw9
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