A microscale device to measure physical properties of epithelial tissue Chao Liu

A microscale device to measure physical properties of epithelial tissue
Chao Liu, Xiaoshan Ke.

Summary and Specific Aims
This page is a template for the Summary and Specific Aims page of the Project Summary. It has the correct margins, spacing, fonts and headings. The font is Arial 11. The spacing is single-spaced. The margins are 0.5″ on the top and sides, 1.0″ on the bottom of the page. The page numbers are in the bottom center starting on the second page with number 1. The Summary and Specific Aims page (i.e., this page) should be no more than 1 page, and it is not numbered. So, the total number of pages will be 2 to 3, with additional space for the references. References do not count towards the 3-page limit. The Project Summary is written individually. The only exceptions are the bold Specific Aims below, which should be written together as a group.
The Summary and Specific Aims page should:

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Concisely state the goals of the proposed research or new design. You may cite your functional requirements, if functional requirements are appropriate for your senior design project.
Summarize the expected outcomes, including impact of the work you propose on fields involved
Succinctly list specific aims of proposed work (e.g., to test a hypothesis, create a
novel design, solve a specific problem, make a new type of measurement possible, diagnose a disease, etc.).

Most projects will have 2-4 Aims. The objectives should be listed on this page. You will repeat the list in the Approach section of the Research/Design Strategy, which is included in the Project Proposal. The Summary and Specific Aims page (i.e., this page) is meant to be a concise summary of what you are proposing to accomplish in 9 months. Discuss these aims with your technical advisor. Make sure you have chosen a set of aims that can be accomplished in the time frame of two semesters.
The wording of the Aims should be the same on this page as in the Approach section. You do not need to fill an entire page of text in this section. You should expect and allow for your aims to change as you revise and rework this proposal over the course of the semester. However, you should have a clear set of aims by December, so that you can start in earnest working on completing them.

Aim 1: Design a proper microscale device consists of three-dimensional MDCK epithelial cell tissue and extracellular matrix (ECM) for testing various physical properties of the tissue.
Aim 2: Test various physical properties on the MDCK epithelial cell tissue using the designed microscale device and verify the results.
Aim 2.a: Perform hydraulic conductivity test.
Aim 2.b: Perform solute permeability test.
Aim 2.c: Perform electrical resistivity test.
Aim 2.d: Perform adhesive strength test.

You may add a short section of concluding remarks here. In this section you may summarize the project, explain how your project will impact your field or other fields if it is successful, or remind the reader of the potential impact of your project.

Research/Design Strategy
The rest of this document is a template for the Research/Design Strategy section of the Senior Design Project Summary. It has the correct margins, spacing, fonts and headings. The font is Arial 11. The spacing is single spaced. The margins are 0.5″ on the top and sides, 1.0″ on the bottom of the page. The page numbers are in the bottom center.

Significance (about ½ page)
Explain the importance of the problem or critical barrier to progress in the field that
the proposed project addresses. (e.g. What is the clinical significance of your project? How will your new design impact future patient health or other research? Will you be able to do measurements using your system that were previously not possible? etc.)
Explain how the proposed project will improve scientific knowledge, technical
capability, and/or clinical practice in one or more broad fields.
Describe how the concepts, methods, devices, diagnostics, instruments, technologies, treatments,
services, or preventative interventions that drive this field will be changed if the proposed objectives
are achieved.

Innovation (about ½ page)
Explain how the proposal challenges and seeks to shift current methods, designs, research or clinical practice paradigms.
Describe any novel theoretical concepts, approaches or methodologies,
instrumentation or intervention(s) to be developed or used, and any advantage over
existing methodologies, instrumentation or intervention(s).
Explain any refinements, improvements, or new applications of theoretical
concepts, approaches or methodologies, instrumentation, technologies, devices or interventions.

The epithelial tissue is the important barrier that preventing harmful chemicals and solutes entering the body. In particular, the cell line derived from kidney tubules, Madin-Darby Canine Kidney (MDCK) epithelial cell line is used to test the effect of the external stimulus.
MDCK cell monolayer is a good model to study renal distal tubule.
Test drug delivery and residual drug removal in the kidney in vitro model.
This project would bring the better understanding how epithelium reacts to changes in its environment. It could potentially use as a biological modeling that can tell how we can simulate the body and what’s happened inside it. it would allow us to repeat the experiments in vivo and avoid the experiment that can be harmful in human body.
The better understanding of the physiological structure, give insights on future work of regenerative biology in epithelium.

References
Use any referencing program you want. For a Project Summary this size, 15-30 references are typical. References should be called out in the text as superscript numbers, like this,. The References section does NOT count towards the 3-page Project Summary page limit.

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